National Cheng Kung University

Faculty
Name An-Shun Tai
Job title Assistant Professor
Expertise Biostatistics, Bioinformatics (Statistical Genomics), Bayesian variable selection, Causal inference, Causal mediation analysis, Mendelian randomization
E-mail ashtai@gs.ncku.edu.tw
Office Room 62445, 4th Floor, Department of Statistics
Tel (06)2757575~53626
Web site https://anshuntai.weebly.com
Main Experiences
  • 2022-now. Assistant Professor, Department of Statistics, National Cheng Kung University.
  • 2019-2022. Postdoctoral Fellow, Institute of Statistics, National Chiao-Tung University, Taiwan.
  • 2017. Predoctoral Visiting Scholar, Department of Biostatistics, University of Pittsburgh.
Education
  • Ph.D. in Institute of Statistics, National Tsing-Hua University, Taiwan. 
  • M.S. in Institute of Statistics, National Tsing-Hua University, Taiwan. 
  • B.S. in  Department of Mathematics, National Tsing-Hua University, Taiwan.
Research Field

 

  • Biostatistics
  • Bioinformatics (Statistical Genomics)
  • Bayesian variable selection
  • Next-generation sequencing (NGS) data analysis
  • Causal inference
  • Causal mediation analysis

(A) Major work († indicates co-first author; * indicates corresponding author)

Published or in press​:

1.    An-Shun Tai and Sheng-Hsuan Lin* (2024+). Multiply robust estimation of natural indirect effects with multiple ordered mediators. Statistics in Medicine.

2.      An-Shun Tai and Sheng-Hsuan Lin* (2023). Complete effect decomposition for an arbitrary number of multiple ordered mediators with time-varying confounders: A method for generalized causal multi-mediation analysis. Statistical Methods in Medical Research. 32(1), 100-117.

3.      An-Shun Tai, Sheng-Hsuan Lin*, Yu-Cheng Chu, Tsung Yu, Milo A. Puhan, and Tyler VanderWeele (January 2023). Causal mediation analysis with multiple time-varying mediators. Epidemiology. 34(1):p 8-19

4.      An-Shun Tai, Ro-Ting Lin*, Yi-Chun Lin, Chung-Hsing Wang, Sheng-Hsuan Lin, Seiya Imoto (2022 Aug 25). Genome-wide causal mediation analysis identifies genetic loci associated with uterine fibroids mediated by age at menarche. Human Reproduction. 37(9):2197-2212. doi: 10.1093/humrep/deac136. (IF=6.353, Rank=4/31)

5.      An-Shun Tai, Pei-Hsuan Lin, Yen-Tsung Huang, and Sheng-Hsuan Lin* (2022). Path-specific effects in the presence of a survival outcome and causally ordered multiple mediators with application to genomic data. Statistical Methods in Medical Research. 31(10):1916-1933. doi:10.1177/09622802221104239

6.      An-Shun Tai, Le-Hsuan Liao, and Sheng-Hsuan Lin* (2022). On the conventional definition of path-specific effects - fully mediated interaction with multiple ordered mediators. Epidemiology. 33(6): p 817-827. DOI: 10.1097/EDE.0000000000001520

7.      An-Shun Tai, Chun-Chao Wang, and Wen-Ping Hsieh* (2022). Detection of cell separation-induced gene expression via a penalized deconvolution approach. Statistics in Biosciences. https://doi.org/10.1007/s12561-022-09344-8.

8.      An-Shun Tai and Sheng-Hsuan Lin* (2022). Identification and robust estimation of swapped direct and indirect effects: Mediation analysis with unmeasured mediator–outcome confounding and intermediate confounding. Statistics in Medicine. https://doi.org/10.1002/sim.9501.

9.      An-Shun Tai, Yi-Juan Du, and Sheng-Hsuan Lin* (2022). Robust inference on effects attributable to mediators: A controlled-direct-effect-based approach for causal effect decomposition with multiple mediators. Statistics in Medicine. https://doi.org/10.1002/sim.9329.

10.   An-Shun Tai, Yen-Tsung Huang, Hwai-I Yang, Lauren V. Lan, and Sheng-Hsuan Lin* (2022). G-computation to causal mediation analysis with sequential multiple mediators – investigating the vulnerable time window of HBV activity for the mechanism of HCV induced hepatocellular carcinoma. Frontiers in Public Health. doi: 10.3389/fpubh.2021.757942.

11.   An-Shun Tai and Sheng-Hsuan Lin* (2021). Integrated multiple mediation analysis: A robustness–specificity trade-off in causal structure. Statistics in Medicine. https://doi.org/10.1002/sim.9079.

12.   An-Shun Tai, Chun-An Tsai, and Sheng-Hsuan Lin* (2021). Survival mediation analysis with the death-truncated mediator: The completeness of the survival mediation parameter. Statistics in Medicine. https://doi.org/10.1002/sim.9008.

13.   An-Shun Tai, George C. Tseng and Wen-Ping Hsieh* (2021). BayICE: A Bayesian hierarchical model for semi-reference-based deconvolution of bulk transcriptomic data. Annals of Applied Statis­tics. 15(1) 391 - 411. https://doi.org/10.1214/20-AOAS1376.

14.   An-Shun Tai, Chien-Hua Peng*, Shih-Chi Peng, and Wen-Ping Hsieh* (2018). Decomposing the subclonal structure of tumors with two-way mixture models on copy number aberrations. PLOS ONE. 13(12): e0206579.

 

Papers in review or in revision:

1.   An-Shun Tai* (2024+). Robust semiparametric estimation of average causal effects in Mendelian randomization under an intermediate variable intervention. In preparation.

2.   Yan-Lin Chen, Yan-Hong Chen, Pei-Fang Su, Huang-Tz Ou, and An-Shun Tai* (2024+). Robust inference for causal mediation analysis of recurrent event data. Submitted.

3.   An-Shun Tai, Yu-Cheng Chu, and Sheng-Hsuan Lin* (2024+). Causal mediation analysis of non-mortality outcomes with follow-up truncated by death: Survivor natural direct and indirect effect. Submitted.

 

(B) Collaborative work

Published or in press​:

1.   Jui-Hsiang Lin, An-Shun Tai, and Sheng-Hsuan Lin* (2022). Population Attributable Fraction based on sufficient causal framework for mediation settings. Annals of Epidemiology. 75:57-66. doi: 10.1016/j.annepidem.2022.08.050.

2.   Tzu-Yen Huang, Wing-Hei Viola, Feng-Yu Chiang, Che-Wei Wu, Shih-Chen Fu, An-Shun Tai, Yi-Chu Lin, Hsin-Yi Tseng, Ka-Wo Lee, Sheng-Hsuan Lin (2021). Correlation between Objective and Subjective High-Pitched Voice Impairment in Patients after Thyroid Surgery.  Frontiers in Endocrinology. Accepted.

3.   Tzu-Yen Huang, Wing-Hei V. Yu, Feng-Yu Chiang, Che-Wei Wu, Shih-Chen Fu, An-Shun Tai, Yi-Chu Lin, Hsin-Yi Tseng, Ka-Wo Lee, and Sheng-Hsuan Lin (2021). How the Severity and Mechanism of Recurrent Laryngeal Nerve Dysfunction during Monitored Thyroidectomy Impact on Postoperative Voice. Cancers 13, no. 21: 5379. https://doi.org/10.3390/cancers13215379

4.   Tanbin Rahman, Hsin-En Huang, Yujia Li, An-Shun Tai, Wen-Ping Hsieh, Colleen McClung, and George C. Tseng* (2021). A sparse negative binomial classifier with covariate adjustment for RNA-seq data. ​Annals of Applied Statistics. Accepted.

5.   Yu-Hsuan Lin, Si-Yu Chen, Pei-Hsuan Lin, An-Shun Tai, Yuan-Chien Pan, Chang-En Hsieh, and Sheng-Hsuan Lin* (2019+). Assessing User Retention of a Mobile App: Survival Analysis. JMIR Mhealth Uhealth. 2020;8(11):e16309. DOI: 10.2196/16309

6.   Yen-Tsung Huang, An-Shun Tai, Meng-Ying Chou, Geng-Xian Lin, and Sheng-Hsuan Lin* (2020) Six‐way decomposition of causal effects: Unifying mediation and mechanistic interaction. Statistics in Medicine. 1– 18. https://doi.org/10.1002/sim.8708.

7.   Chien-Hua Peng, Chun-Ta Liao, Ka-Pou Ng, An-Shun Tai, Shih-Chi Peng, Jen-Pao Yeh, Shu-Jen Chen, Kuo-Chien Tsao, Tzu-Chen Yen*, and Wen-Ping Hsieh* (2015). Somatic copy number alterations detected by ultra-deep targeted sequencing predict prognosis in oral cavity squamous cell carcinoma. Oncotar­get, 6(23), 19891.

8.   Chien-Hua Peng, Yi-Zhi Jiang, An-Shun Tai, Chun-Bin Liu, Shih-Chi Peng, Chun-Ta Liao, Tzu-Chen Yen*, and Wen-Ping Hsieh* (2013). Causal inference of gene regulation with subnetwork assem­bly from genetical genomics data. Nucleic Acids Research.

 

Papers in review or in revision:

1.   Hyunman Sim, Whanhee Lee, An-Shun Tai, Woojoo Lee (2024+). Sensitivity analysis for attributable fraction in the presence of unmeasured confounding. Revision in American Journal of Epidemiology.

2.   Pei-Hsuan Hsia, An-Shun Tai, Chu-Lan Micheal Kao, Yu-Hsuan Lin, and Sheng-Hsuan Lin* (2024+). Causal Mediation Analysis for Difference-in-Difference Design and Panel Data. Revision in Journal of Causal Inference.

 

(C) Other work

1.   An-Shun Tai, Shih-Wen Lin, and Sheng-Hsuan Lin* (2020) Sample Size Calculations for the Multiple Mediation Model (in Chinese). JCSA. Vol. 58, 199–220.

2.   An-Shun Tai, Yen-Tsung Huang, Wen-Chung Lee, and Sheng-Hsuan Lin* (2020) Conceptualization of agonistic interaction under marginal sufficient component cause model – an alternative interpreta­tion for subadditive interaction. JCSA. Vol. 58, 168–198.

3.   An-Shun Tai and Sheng-Hsuan Lin* (2022) Book review: “Fundamentals of Causal Inference With R” by Babette A. Brumback. Biometrics. https://doi. org/10.1201/9781003146674

Honor
  • 2021 MOST Postdoctoral Researcher Academic Research Award